Mal-Propionyl-Dap(m-PEG4)-Val-Cit-OH Size:50mg 03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC)

03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

325 SMILES OCCC#CC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name MaP555-Alkyne Synonyms CAS Number n/a Related CAS Molecular Formula C30H31N5O5S Molecular Weight 573

NCCOCCOCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

89 SMILES Cl

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-OH Size:50mg 03 SMILES C[C@H]1CN(C[C@@H](C)C1(F)F)C1=NC(NC2=CC3=C(C=C2)N(C)C(=O)N3CCC(C)(C)C)=C(Cl)C=N1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine