Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:25mg CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2S(O)(=O)=O)S(=O)(=O)NCCN)=[N](CC)CC)=C1 Purity (HPLC): ≥ 95%

CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2S(O)(=O)=O)S(=O)(=O)NCCN)=[N](CC)CC)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE Synonyms CAS Number Related CAS Molecular Formula C89H151N15O27 Molecular Weight 1863

73 SMILES: CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2S([O-])(=O)=O)S(=O)(=O)NCC#C)=[N+](CC)CC)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

399 SMILES OCCCCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Thalidomide-O-acetamido-propargyl Synonyms Thalidomide-4'-O-acetamido-propargyl CAS Number n/a Related CAS Molecular Formula C18H15N3O6 Molecular Weight 369

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-PNP Size:25mg CCN(CC)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2S(O)(=O)=O)S(=O)(=O)NCCN)=[N](CC)CC)=C1 Purity (HPLC): ≥ 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para